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Friday, December 01, 2023

Forbes built a hall of shame for all the questionable people on its 30 Under 30 lists | How Anxiety Traps Us, and How We Can Break Free | You're (Maybe) Gonna Need a Patent for That Woolly Mammoth | Wall Street's dream of 'immaculate disinflation' is becoming reality and the economy is doing a lot better than people think, Nobel economist Paul Krugman says

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You're (Maybe) Gonna Need a Patent for That Woolly Mammoth - WIRED   

The mouse didn't look like much. It had the same red beady eyes and white fur as any other laboratory mouse. Sure, its DNA had been tweaked to make it ideal for testing anti-cancer drugs, but that wasn’t so unusual either. The year was 1988, and it had been more than a decade since researchers at the Salk Institute showed it was possible to create genetically modified mice by inserting viral DNA into mouse embryos. Plenty of other genetically modified animals would be created in the following decades, but none of them would prove as important—or controversial—as OncoMouse.

What made OncoMouse remarkable was its paperwork. On April 12, 1988, the US Patent and Trademark Office issued a patent for it—the first for any living animal. The patent turned a mouse—which had been modified to be more susceptible to cancer—into a legally protected invention, with a patent that prevented anyone else from making or selling mice with the same genetic tweaks. (Or, at least for the 20 or so years that most patents last.) The patent was granted to Harvard University, which passed on the exclusive license to the main funder of its research: DuPont. Soon, the chemical giant was printing T-shirts with an OncoMouse silhouette emblazoned across the chest, and selling researchers the new invention for $50 a mouse.

That patent changed science forever. After OncoMouse, scientists rushed to invent—and patent—other animals that would be useful in their research. Mostly this meant mice, but occasionally other species were patented too, as in the case of rabbits engineered to be susceptible to HIV infection. OncoMouse was used in countless breast cancer studies and helped researchers understand the genetics behind human susceptibility to cancer.

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