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Thursday, August 10, 2023

Study mapping how SARS-CoV-2 disrupts mitochondria suggests a cause for long Covid | Are your hormones unbalanced—and what does that even mean? | 3 Habits that May Be Derailing Your Career

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Study mapping how SARS-CoV-2 disrupts mitochondria suggests a cause for long Covid   

In yet another example of Covid’s seemingly limitless reach into our bodies, new research maps out how the SARS-CoV-2 virus disrupts mitochondria, the power plants in all our cells. The extent of the damage, spanning the lungs, heart, liver, kidneys, and brain, could potentially be one explanation for the lengthy list of persistent symptoms of long Covid, from fatigue to brain fog.

Covid is often considered an inflammatory illness, and theories about what might cause long Covid center on the virus lingering in reservoirs within the body, collateral damage from an overactive immune response to acute infection, and auto-antibodies that turn on the body with misdirected protective force. The study published Wednesday in Science Translational Medicine builds on work showing SARS-CoV-2 can change the structure of mitochondria and hamper energy generation. It goes further to define the genetic mechanism that damages mitochondria in organs, leading to more severe disease and perhaps long Covid.

“What I think this paper does is cement the case for mitochondria as being one of the root causes of long Covid,” Eric Topol, director of the Scripps Research Translational Institute, told STAT. He was not involved in the study. “What we don’t know is whether or not this accounts for X percent, in which people who have mitochondrial dysfunction and key root cause. But I think this study really advances the notion that at least in some people, the mitochondrial effects of infection are playing a role.”

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