"Inverse vaccine" shows potential to treat multiple sclerosis and other autoimmune diseases | Warren Buffett's advice for avoiding major mistakes: 'Write your obituary and figure out how to live up to it' | How the fentanyl crisis' fourth wave has hit every corner of the US

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You Might Like � � � You Might Like � � � � � � � � � Don't like ads? Go ad-free with TradeBriefs Premium "Inverse vaccine" shows potential to treat multiple sclerosis and other autoimmune diseases -     A new type of vaccine developed by researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis and type 1 diabetes— all without shutting down the rest of the immune system. A typical vaccine teaches the human immune system to recognize a virus or bacteria as an enemy that should be attacked. The new “inverse vaccine” does just the opposite: it removes the immune system’s memory of one molecule. While such immune memory erasure would be unwanted for infectious diseases, it can stop autoimmune reactions like those seen in multiple sclerosis, type I diabetes, or rheumatoid arthritis, in which the immune system attacks a person’s healthy tissues. The inverse vaccine, described in Nature Biomedical Engineering, takes advantage of how the liver naturally marks molecules from broken-down cells with “do not attack” flags to prevent autoimmune reactions to cells that die by natural processes. PME researchers coupled an antigen — a molecule being attacked by the immune system— with a molecule resembling a fragment of an aged cell that the liver would recognize as friend, rather than foe. The team showed how the vaccine could successfully stop the autoimmune reaction associated with a multiple-sclerosis-like disease. Continued here You Might Like � � � � � � � � � Warren Buffett's advice for avoiding major mistakes: 'Write your obituary and figure out how to live up to it' - CNBC    Each spring, investors in multinational conglomerate Berkshire Hathaway flock to the firm's annual shareholder meeting. Some attend in the hopes of getting a clearer picture of the fundamentals of the business they're invested in. The majority, though, are there to hear from 92-year-old chairman and CEO Warren Buffett, who, in his enormously successful, decades-long career has become an icon of the investing world — someone who can tell us not only how to make more money, but also how to live a better life. They don't call him the Oracle of Omaha for nothing. In his annual letter to shareholders this year, Buffett posited that much of his firm's success resulted from his and his colleagues' avoidance of "major mistakes." When asked at Saturday's meeting how to avoid such mistakes in investing and in life, Buffett offered a thoughtful response. Continued here You Might Like � � � � � � � � � How the fentanyl crisis' fourth wave has hit every corner of the US - BBC    More Americans than ever are dying from fentanyl overdoses as the fourth wave of the opioid epidemic crashes through every community, in every corner of the country. It was six years ago that Kim Blake's son Sean died from an accidental fentanyl overdose in Burlington, Vermont. He was 27 years old. "Every time I hear of a loss to substance use, my heart breaks a little more," Ms Blake wrote in a blog dedicated to her son in 2021. Continued here

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